- Longtime Cardinals owner Bill Bidwill died on Wednesday at the age of 88. Bidwill had owned the team since 1972, though his son, Michael Bidwill, had been operating the franchise in recent years.
- Kyler Murray earned his first NFL win on Sunday, as did head coach Kliff Kingsbury.
- David Johnson said his back locked up on him throughout Sunday's game, but he still managed to total 154 yards from scrimmage.
- Dan Quinn's defense continues to struggle as he calls the plays, surrendering 40 points to the Texans on Sunday.
- Atlanta is off to a 1-4 start, undoubtedly putting Quinn's job in jeopardy without a serious turnaround. However, owner Arthur Blank said he doesn’t feel a change is necessary at this point.
- While a change is not imminent, the Falcons would have options if they decided to dismiss Quinn midseason - three former head coaches are on Quinn's staff (Dirk Koetter, Mike Mularkey, Raheem Morris).
- The Falcons are only 1.5-point favorites against a Cardinals team with just a narrow victory over the winless Bengals.
- Safety Tony Jefferson suffered a torn ACL in Sunday's win over Pittsburgh.
- Lamar Jackson tied Robert Griffin III, his backup, as the fastest quarterback to reach 1,000 career rushing yards (21 games). Of course, Jackson has only started twelve of those games.
- Jackson has thrown five interceptions across his last two games, after a dominant start to the season.
- The Bills head into their bye week at 4-1, well-positioned with a matchup against Miami awaiting in Week 7.
- Buffalo could use some improvement from Josh Allen if they want to make serious noise. Allen has five touchdowns and seven interceptions through five games.
- Rookie running back Devin Singletary was inactive with a hamstring injury on Sunday, but he was close enough that a return following the bye is expected.
- The Panthers lost defensive tackle Kawann Short to season-ending rotator cuff surgery last week.
- Kyle Allen is now 4-0 as an NFL starter and 3-0 in place of Cam Newton this season.
- Christian McCaffrey is emerging as an MVP candidate after a 237-yard, three-touchdown performance. McCaffrey is now on pace for 2,771 scrimmage yards, which would set the single-season record.
- Mitchell Trubisky missed Sunday's game in London, as expected, but the hope is that he'll be able to return after the upcoming bye week.
- Khalil Mack recovered a fumble against his former team, but the Raiders had the last laugh in a game in which they allowed zero sacks.
- The Bears allowed 169 rushing yards in Sunday's loss, the most they have let up since Week 12 of 2017.
- The Bengals made up a 14-point deficit in short order against the Cardinals, but a last-second field goal sent them to 0-5 for the first time since 2008.
- A.J. Green, recovering from summer ankle surgery, will not play in Week 6.
- Zac Taylor is still winless as an NFL head coach, but he's joined by Brian Flores and Adam Gase as newly-hired head coaches yet to win a game with their new team.
- Baker Mayfield posted easily the worst passer rating of his career on Monday night, 13.4. Mayfield now has four touchdowns and a league-high eight interceptions this season.
- Nick Chubb has yet to slow down, running for 87 yards on Monday to bring his season total to 485 rushing yards through five games.
- It's been difficult to get a read on the Browns this season as they follow this loss-win-loss-win-loss track, and they'll draw another powerful NFC West opponent in the Seahawks in Week 6.
- Amari Cooper had himself a day despite the loss to Green Bay, racking up 226 receiving yards and a touchdown.
- Cooper is nearing a full season in a Cowboys uniform, with impressive totals of 1,237 yards and 11 touchdowns across 14 games.
- Sunday marked Dak Prescott's second career game with three interceptions, the first coming in an ugly 2017 loss to the Eagles.
- Prescott set a career-high with 463 passing yards on Sunday. Entering Week 5, the Cowboys had won every game in which Prescott had thrown for more than 275 yards since he entered the league in 2016.
- Vic Fangio earned his first win as an NFL head coach on Sunday, receiving the game ball from GM John Elway.
- Second-year receiver Courtland Sutton has been among the NFL's most reliable targets this season, totaling at least four receptions and 60 yards in four of his five games. Sutton is on a nearly 1,300-yard pace.
- Fangio had said he felt the Broncos were close despite an 0-4 start, and the team backed up that notion by holding the Chargers to 13 points in the wake of Bradley Chubb's season-ending injury.
- The Lions have an extra week to prepare for the spotlight in Week 6, a Monday night road matchup with Green Bay that could either send them to .500 or into the division lead.
- Rookie tight end T.J. Hockenson was not placed on IR after suffering a concussion and shoulder injury against the Chiefs in Week 4, but he does not yet have a timetable for a return.
Green Bay Packers
- Davante Adams missed Sunday's game, as had been expected, due to a toe injury. He remains week-to-week.
- Aaron Jones carried the load for Green Bay, scoring four touchdowns and totaling 182 yards from scrimmage.
- Aaron Rodgers has thrown for more than 250 yards in only one of five games this season, but the Packers' approach is working as they head into Week 6 in sole possession of first place in the NFC North.
- Will Fuller V had a career day in Sunday's win, hauling in 217 yards and three touchdowns on 14 receptions.
- Deshaun Watson already has three games with five touchdowns and zero interceptions in his brief career.
- Watson was not sacked in Sunday's victory, only the second such occurrence in his career. In those two games, Watson has thrown ten touchdowns and no interceptions.
- The Colts recovered from a tough home loss against Oakland to shut down the Chiefs on the road, holding Kansas City to 13 points in a stellar win.
- Marlon Mack, who ran for 132 yards against the Chiefs, is on a 1,500-yard rushing pace through five games.
- Indianapolis is tied atop the AFC South with the Texans at 3-2 heading into their bye week.
- Despite the loss, Gardner Minshew threw for 374 yards against the Panthers.
- D.J. Chark has emerged as one of this season's breakout stars. The second-year receiver had 164 yards and two touchdowns on Sunday, bringing his season total to 485 yards and five touchdowns through five games.
- Leonard Fournette is one of three players with more than 500 rushing yards through five weeks.
- Jalen Ramsey's trade request still stands, and while he was pictured in Houston with Deshaun Watson on Sunday, the Jaguars are reportedly not entertaining offers. Ramsey has missed two games with what's been labeled a back injury.
Kansas City Chiefs
- After throwing ten touchdowns in the opening three games, Patrick Mahomes has only put one score on the board in the last two weeks. Still, he has yet to throw an interception.
- Mahomes aggravated an ankle injury in the second half of Sunday night's loss, but it was described as only a "tweak" by Andy Reid.
- Defensive end Chris Jones is expected to miss time after suffering a groin injury against the Colts.
- A Chiefs defense that was trampled by Marlon Mack will now have to face a high-octane Texans passing attack in Week 6.
Los Angeles Chargers
- The Chargers are one loss away from matching their 2018 total (4), after another sluggish performance on Sunday.
- Melvin Gordon ran for only 31 yards on 12 carries in his first game back on the field since returning from a holdout.
- Philip Rivers threw 48 passes against the Broncos but averaged just 4.4 yards/attempt, his lowest mark in any start since 2007.
Los Angeles Rams
- The Rams have lost consecutive games for only the second time under Sean McVay.
- Cooper Kupp has totaled at least 100 receiving yards in four consecutive games, an impressive stretch after suffering a torn ACL last November.
- NFC Championship Game hero Greg Zuerlein has now missed three field goals in five games, after missing four all of last season.
- One of the Dolphins' best opportunities for a win will come in Week 6, when they face the 0-5, Gruden-less Redskins.
- For as ugly as they've played, Miami is still accompanied by three winless teams in the race toward the top of the draft, as the Bengals, Redskins, and Jets are all still in search of a victory.
- Kirk Cousins heard the criticism and got back on track, at least for now, going 22-of-27 for 306 yards and two touchdown in a win over the Giants.
- Adam Thielen recorded his first 100-yard game of the season, totaling 130 yards and two touchdowns thanks to a huge first half. Thielen had just six yards in Week 4's loss to the Bears.
- Dalvin Cook similarly returned to form after struggling against Chicago, totaling 218 yards from scrimmage against the Giants.
New England Patriots
- New England placed Stephen Gostkowski on IR with a season-ending hip injury prior to Week 5, signing veteran kicker Mike Nugent to take his place.
- Tom Brady was sacked four times in Sunday's win, the most sacks he's taken in a game since Week 3 of the 2017 season.
- The Patriots are the AFC's only undefeated team through five weeks, and they head into Thursday night's matchup with the Giants as 16.5-point favorites.
- There's no disputing the Patriots' ability, but their opponents outside of the Bills have a combined one win through five weeks; the Dolphins, Jets, Steelers, and Redskins are a combined 1-17.
New Orleans Saints
- Teddy Bridgewater was serenaded with chants of "Teddy" at the Superdome, during the second four-touchdown performance of his career.
- Michael Thomas is back on a torrent pace after posting 182 yards and two touchdowns in Sunday's win, as he's now up to a league-best 543 yards through five games.
- The Saints are now 3-0 in games without Brees as their starter, but Brees posted a video this week showing himself throwing a football - a sign of tremendous progress following thumb surgery.
New York Giants
- Daniel Jones suffered his first defeat as an NFL starter on Sunday, throwing for only 182 yards on 38 pass attempts.
- Saquon Barkley hasn’t been ruled out for Thursday night's game against New England as his recovery from a high-ankle sprain continues to shatter expectations.
- Sterling Shepard is unlikely to play against the Patriots on Thursday after being placed in the concussion protocol.
New York Jets
- Sam Darnold practiced with the starters on Wednesday and Thursday despite not being cleared to play, leaving Luke Falk with only one day of first-team practice reps ahead of Sunday's game.
- Luke Falk was sacked ten times in Sunday's loss, the most sacks the Jets have allowed since 2012, when Greg McElroy was taken down eleven times.
- The Jets have some reinforcements on the way, as Quinnen Williams returned on Sunday and tight end Chris Herndon's four-game suspension has ended. Darnold also seems to be on track to play in Week 6.
- The Jets are 0-4 for the first time since 2003, and they'll be looking for their first home win in 364 days when they host the Cowboys in Week 6.
- The Raiders stunned the Bears in London, blowing a 17-0 lead in the span of a quarter before re-gaining the lead and holding on.
- Oakland has won consecutive games for the first time in Jon Gruden's second tenure and is one win away from matching its 2018 win total.
- Rookie running back Josh Jacobs continue to excel, as he heads into the bye week with 430 rushing yards after a 123-yard, two-touchdown performance against a tough Bears run defense.
- The Eagles made quick work of the Jets and have moved into a tie with Dallas atop the NFC East.
- Offseason acquisition Jordan Howard has scored five touchdowns in his last three games.
- DeSean Jackson, who put up 154 yards and two touchdowns in Week 1 but has dealt with an abdominal injury since, is reportedly unlikely to play in Week 6.
- Quarterback Mason Rudolph seemed to be unconscious after taking a hit during Sunday's loss, causing a terrifying scene, but he was alert and talking after a few minutes.
- Devlin Hodges, undrafted out of Samford, stepped in and will presumably get the start in Week 6 if Rudolph is unable to play. Hodges didn't look overwhelmed in his brief time on the field, finishing 7-of-9 for 68 yards.
- If Rudolph is unable to play, Hodges' first NFL start will come on Sunday Night Football against a scuffling Chargers team.
- Paxton Lynch is expected to be added to the 53-man roster as Hodges' backup ahead of Week 6 if Rudolph is indeed ruled out.
San Francisco 49ers
- The 49ers are one of two remaining undefeated teams after their Monday night drubbing of the Browns, sitting at 4-0 through five weeks.
- Nick Bosa erupted against Cleveland, recording two sacks, a forced fumble, and a fumble recovery, also grabbing attention with his sack celebration mocking Baker Mayfield's infamous flag-plant against Ohio State.
- Robbie Gould went 1/4 on field goal attempts on Monday night, after missing only one last season. In his defense, snapping issues contributed.
- Not only are the 49ers undefeated, but they have won three of their four games by at least two touchdowns. Their Week 6 matchup with the Rams could be a great one.
- Tyler Lockett made one of the season's best catches on Thursday night, somehow keeping both feet in bounds while leaning out of the end zone to haul in a touchdown early in the game.
- Russell Wilson has yet to throw a touchdown through five games, and Thursday marked only his second 4-TD performance in his last 30 regular season games.
- Wilson is looking like an MVP candidate alongside Patrick Mahomes and Christian McCaffrey - he's thrown for 12 touchdowns and zero interceptions while completing 73% of passes on the year.
Tampa Bay Buccaneers
- Chris Godwin recorded his third game of at least 120 receiving yards this season, bringing his total to 511 yards through five games.
- Tampa's loss marked an eighth consecutive season with a losing record through five games.
- The Buccaneers head to London this week for a divisional matchup with Carolina, a morning game on the east coast.
- Cairo Santos cost the Titans a win in a close battle with the Bills, going 0-for-4 on field goal attempts. The performance cost him his job, as Santos was released on Monday.
- Here's a fun one: Cody Parkey, who infamously double-doinked the last-second field goal in the Bears' playoff loss to the Eagles this past January, is being signed as Santos' replacement.
- Taylor Lewan returned from suspension on Sunday and got into a Twitter spat with Buffalo's Shaq Lawson and Jordan Phillips following the loss.
- Since scoring 43 points in a Week 1 win over the Browns, Tennessee has scored 55 points across four games - including two seven-point showings.
- The Redskins fired head coach Jay Gruden early Monday morning, after an 0-5 start. Gruden was in his sixth season with Washington and finishes his tenure with a record of 35-49-1. Bill Callahan was named the team's interim coach.
- Colt McCoy got the start against New England, a week after Case Keenum was benched and Dwayne Haskins struggled in his place. Callahan will determine the starter going forward, but Haskins has been ruled out.
- In regard to his job status, Jay Gruden said Sunday, "If the key works Monday, I'll keep working." That line is becoming the kiss of death - Ben McAdoo said nearly the same less than 24 hours before his firing in 2017.
- The Redskins are the NFC's only winless team and one of two five-loss teams, alongside the Bengals. Someone will have to win when they take on the 0-4 Dolphins in Week 6.